Nodular cutaneous amyloidosis effectively treated with intralesional methotrexate

LFT: liver function test PLCNA: primary localized cutaneous nodular amyloidosis INTRODUCTION Amyloidosis is a group of conditions that involve the deposition of amyloid proteins in various tissues. It is generally classified as either systemic or cutaneous. Primary localized cutaneous nodular amyloidosis (PLCNA) is the rarest form of cutaneous amyloidosis with the amyloid depositing in the dermis, subcutis, and blood vessel walls. Management of PLCNA is challenging, as there is no consistently effective treatment, and local recurrence is common. Management options include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy, carbon dioxide laser, pulse dye laser, intralesional steroids, and cyclophosphamide. We report a case of PLCNA in which intralesional methotrexate has been used with good effect.